Hello, I’m Dr. Yoo. The effects of Botox on scar prevention and treatment are increasingly being announced.Let’s find out how Botox, which has been used to improve functional problems such as strabismus and cosmetic problems such as skin wrinkles, affects scar prevention.
Botox is a toxin that comes from bacteria (Clostridium botulinum). There are seven types, the most famous and widely used of which is Botulinum toxin type A. At first, it was approved for treatment by strabismus patients, but recently, administration for cosmetic purposes such as improving wrinkles between eyebrows was also approved by the FDA. Botox used for other purposes corresponds to off-label use, or indications other than permitted use. Botox used in scarring is also off-label, and research on its effects and mechanisms is currently underway.
Before you know the effect of the scarlet, you must know the basic process of scar.Generally, scar is that the skin is normal to recover from the skin before the skin is successful.There are also a rough jump and the opposite.There are various scarlet, but it is targeted to target for the fat scarlet research, but it is targeted at Botox research.If the skin, the skin is added, the skin is added to the skin, the skin is to participate in this process.In that, the most important cell is the most important transmission material is GF-B1.Therefore, the generation of the fiber germ cells and activities can be over, and activities can be increased, and the GF-B1 can be increased.
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Fibroblasts stimulated by the transmitter gather in greater numbers and cause excess collagen. Conversely, the number of fibroblasts that should disappear naturally decreases. What makes this process worse is the mechanical tension stress applied to the wound, which is one of the causes of muscle movement around the skin.
Research papers published so far can infer the mechanism and effect of Botox acting in this process. 1. Decrease muscle movement under the skin (macroeffect) 2. Suppress fibroblasts, decrease TGF-B1 (microeffect)
Compare two papers on the effect of Botox on scar prevention after thyroid surgery. These are the papers published in Korea in 2014 and Canada in 2019. The 2014 paper argued on the scar prevention effect of Botox, and the 2019 paper argued that it only works in patients with severe scarring history. It is natural that the results of the two research papers are different because the number of N is different from that of the target race (Korean/Canadian) and there is also a difference in dosage. However, both studies acknowledged the significance of the Botox effect and stressed that additional research should go further.
Let’s take a look at what Hallym University Medical College published in the international orthopedic journal PRS in 2019. Based on a number of previous studies, the study was conducted assuming that there was a definite Botox effect on thyroid scar prevention. The most important point in this paper is not whether or not Botox is effective, but at which point it is most effective. The patients who received Botox immediately on the day of surgery were able to achieve better results than the control group who received Botox two weeks later.
To sum up, a study on scar prevention in thyroid surgery has been published. There are differences over the degree of Botox effect and various factors involved. However, it is recognized to be effective. Currently, studies are underway on the timing and dosage of administration.To sum up, a study on scar prevention in thyroid surgery has been published. There are differences over the degree of Botox effect and various factors involved. However, it is recognized to be effective. Currently, studies are underway on the timing and dosage of administration.